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Synlett 1999; 1999(11): 1808-1810
DOI: 10.1055/s-1999-2922
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Structure-Activity Investigations of Analogues of the C15-C26 Phorboxazoles Segment

P. Wolbers* , H. M. R. Hoffmann, F. Sasse
  • *Department of Organic Chemistry, University of Hannover, Schneiderberg 1 B, D-30167 Hannover, Germany; Fax +49 (0) 5 11 7 62 30 11; E-mail: hoffmann@mbox.oci.uni-hannover.de
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Publication Date:
31 December 1999 (online)

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A variety of analogues of phorboxazole C15-C26 segment have been prepared via three different reaction sequences. Structure activity investigations of the oxazole substitution pattern point to a pharmacophoric lead structure.

oxazole synthesis - drug discovery - natural products - SAR-studies